|
rs7034162
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphism rs7034162 was associated with metastasis of osteosarcoma in the Chinese population possibly via downregulation of <i>NFIB</i>.
|
31522615 |
2019 |
|
rs4730222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that the most significant SNP, rs4730222, exhibits differential nuclear protein binding in electrophoretic mobility shift assays and drives increased expression of an alternative isoform of HBP1 in a heterozygote chondrosarcoma cell line, in a CRISPR-edited osteosarcoma cell line, and in chondrocytes derived from osteoarthritis patients.
|
31164647 |
2019 |
|
rs1215600806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs1215600806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs1416572796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs143358506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs143358506
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs764191858
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs779591039
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Plasmids created for mutants 1 c.110T>C (L37P), 2 c.532T>C (Y178H) and 3 c.715G>T (D239Y) using in vitro mutagenesis were transfected into human osteosarcoma (U<sub>2</sub>OS) cells and compared to wildtype (WT) and mock cDNA.
|
31146036 |
2019 |
|
rs1273593548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Methods:</b> Osteosarcoma cancer cell line MG-63 was transfected with Ras gene with G12V and Y40C site mutation.
|
31126199 |
2019 |
|
rs367597251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Methods:</b> Osteosarcoma cancer cell line MG-63 was transfected with Ras gene with G12V and Y40C site mutation.
|
31126199 |
2019 |
|
rs756673959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Methods:</b> Osteosarcoma cancer cell line MG-63 was transfected with Ras gene with G12V and Y40C site mutation.
|
31126199 |
2019 |
|
rs1128503
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The <i>ABCB1</i> (C1236T) polymorphism affects P-gp-mediated transport of osteosarcoma drugs in a drug-specific way.
|
30977678 |
2019 |
|
rs1042522
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present meta-analysis, we aimed to elucidate the associations of TP53 rs1042522 genetic polymorphism with the risk of osteosarcoma or Ewing sarcoma.
|
30833364 |
2019 |
|
rs3217992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RESULTS An allele of the SNP rs3217992 is predictive for susceptibility to osteos</span>arcoma, and it is associated with poorer prognosis of osteos</span>arcoma.
|
30774116 |
2019 |
|
rs770771727
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Fresh mitochondria isolated from homeoplasmic 143B osteosarcoma cybrids containing mitochondrial DNA (mtDNA) derived from health individuals (Mito) or mtDNA with the A8344G mutation (Mito<sup>8344</sup>) were conjugated with cell-penetrating peptide Pep-1 (P-Mito) or not conjugated prior to cell co-culture.
|
30674338 |
2019 |
|
rs1799793
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study did not support rs11615, rs13181 or rs1799793 to be used as surrogate markers for clinical outcome of osteosarcoma with chemotherapy.
|
30544402 |
2018 |
|
rs13181
|
|
|
0.080 |
GeneticVariation |
BEFREE |
This study did not support rs11615, rs13181 or rs1799793 to be used as surrogate markers for clinical outcome of osteosarcoma with chemotherapy.
|
30544402 |
2018 |
|
rs861539
|
|
|
0.040 |
GeneticVariation |
BEFREE |
XRCC3 Thr241Met gene polymorphism was associated with osteosarcoma risk, but XRCC3 Thr241Met CC genotype was not associated with Enneking stage, tumor location, and tumor metastasis.
|
30539867 |
2018 |
|
rs1799782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Besides, no significant association of rs25487, rs1799782, and rs25489 with OS was observed.
|
30464596 |
2018 |
|
rs25489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Besides, no significant association of rs25487, rs1799782, and rs25489 with OS was observed.
|
30464596 |
2018 |
|
rs3213245
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, these findings revealed that XRCC1 rs3213245 polymorphism was associated with increased risk of OS, which could affect XRCC1 expression in vitro and in vivo.
|
30464596 |
2018 |
|
rs11615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ERCC2-rs1799793 AA+AC > CC (OR=1.3428, 95% CI=1.0201; 1.7674) had an effect on the risk of osteosarcoma development, whereas, there were no significant associations among the other ERCC SNPs (ERCC1 rs3212986, ERCC1 rs11615, and ERCC2 rs13181) and osteosarcoma.
|
30402838 |
2018 |
|
rs1799793
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ERCC2 rs1799793 polymorphism is related to the high risk of osteosarcoma development.
|
30402838 |
2018 |
|
rs13181
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The ERCC2-rs1799793 AA+AC > CC (OR=1.3428, 95% CI=1.0201; 1.7674) had an effect on the risk of osteosarcoma development, whereas, there were no significant associations among the other ERCC SNPs (ERCC1 rs3212986, ERCC1 rs11615, and ERCC2 rs13181) and osteosarcoma.
|
30402838 |
2018 |